Linked Life Data

3257905

Source:http://linkedlifedata.com/resource/pubmed/id/3257905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-4-12
pubmed:abstractText
The role of CD2 antigen in T-cell activation was investigated using soluble-phase or cross-linked monoclonal anti-CD2 antibodies. Soluble-phase anti-CD2 inhibited T-cell activation when accessory signals were provided with accessory cells and not when 12-0-tetradecanoyl-phorbol-13-acetate provided the accessory signals to anti-CD3-treated T cells. Soluble-phase anti-CD2 also inhibited anti-CD3 and accessory cell-dependent increases in intracellular free calcium concentration. Crosslinked anti-CD2, on the other hand, mediated an increase in the concentration of intracellular free calcium in T cells. Crosslinked anti-CD2 also functioned as an accessory cell substitute in that it generated the required accessory signals and mediated significant proliferation of anti-CD3-treated T cells. Collectively, these findings support the concept that the CD2 antigen is a receptor for accessory cells and participates in accessory signal generation and/or transduction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-22
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
T-cell differentiation antigen cluster 2 (CD2) is a receptor for accessory cells and can generate and/or transduce accessory signals.
pubmed:affiliation
Rogosin Institute, Cornell University Medical College, New York 10021.
pubmed:publicationType
Journal Article