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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-4-5
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pubmed:abstractText |
B cell stimulatory factor 1 (BSF-1) (IL-4) was shown to synergize with phorbol esters or with monoclonal anti-TCR antibody in stimulation of the development of CTL from small resting murine T cells. IL-2 also synergized with PMA in such differentiation but was less effective than BSF-1. The combination of these two lymphokines with PMA had the most potent effect on the development of CTL. BSF-1 plus PMA stimulated a significant increase in the intracellular content of N-benzyloxycarbonyl-L-lysine thiobenzylester esterase, a granule-associated biochemical marker, whereas IL-2 plus PMA was only marginally effective. Depletion of L3T4+ cells did not result in the abrogation of these effects. Lyt-2+ T cells that were incubated for 72 h with BSF-1 plus PMA accumulated N-benzyloxycarbonyl-L-lysine thiobenzylester esterase and secreted this intragranular marker after interaction with immobilized anti-T cell receptor mAb. These BSF-1/PMA-stimulated Lyt-2+, L3T4- T cells were also able to kill FcR positive target cells in a retargeting assay with a mAb to murine T3 Ag, providing evidence that BSF-1 plus PMA acted directly on precursors of cytotoxic T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1101-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3257770-Animals,
pubmed-meshheading:3257770-Antibodies, Monoclonal,
pubmed-meshheading:3257770-Antigens, Ly,
pubmed-meshheading:3257770-Cell Differentiation,
pubmed-meshheading:3257770-Cytotoxicity, Immunologic,
pubmed-meshheading:3257770-Drug Synergism,
pubmed-meshheading:3257770-Female,
pubmed-meshheading:3257770-Granzymes,
pubmed-meshheading:3257770-Interleukin-2,
pubmed-meshheading:3257770-Interleukin-4,
pubmed-meshheading:3257770-Interleukins,
pubmed-meshheading:3257770-Mice,
pubmed-meshheading:3257770-Mice, Inbred BALB C,
pubmed-meshheading:3257770-Receptors, Antigen, T-Cell,
pubmed-meshheading:3257770-Serine Endopeptidases,
pubmed-meshheading:3257770-T-Lymphocytes,
pubmed-meshheading:3257770-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3257770-Tetradecanoylphorbol Acetate
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pubmed:year |
1988
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pubmed:articleTitle |
B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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