Linked Life Data

3254432

Source:http://linkedlifedata.com/resource/pubmed/id/3254432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-8-29
pubmed:abstractText
Abrupt changes in the concentration of intracellular calcium, through the mediation of calmodulin, is presumed to play an essential role in many molecular processes in eukaryotes including triggering cell cycle events. Although early studies failed to establish any role for calcium in the growth of bacteria, recent studies have demonstrated that bacteria have several calcium transport systems, and an intracellular concentration of free calcium identical to that of higher organisms, which appears to fluctuate during the cell cycle. Moreover, calmodulin-like proteins have been reported in bacteria, and the growth of E. coli is sensitive to calmodulin inhibitors. In this article we propose that a single flux of calcium, abruptly raising the intracellular concentration of free calcium, is responsible for the triggering in bacteria of the major cell cycle events, initiation of DNA replication, chromosome partition and cell division. We predict that major roles in this process will involve a bacterial calmodulin-like protein and a primitive cytoskeleton. The mechanism of triggering different cell cycle events by a single calcium flux is discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-5193
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-50
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
A single calcium flux triggers chromosome replication, segregation and septation in bacteria: a model.
pubmed:affiliation
Department of Genetics, University of Leicester, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't