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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-8-25
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pubmed:abstractText |
Two series of derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid (1) have been synthesized. The acetyl derivative (2) of ester 1 in preliminary pharmacological screening showed analgesic activity in the "writhing" test and the benzoyl derivative (5) exhibited antianxiety properties in the four plate test, while N,N-disubstituted aminoacetyl derivatives of 1 showed analgesic and anticonvulsant activity (10).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3253716-Analgesics,
pubmed-meshheading:3253716-Animals,
pubmed-meshheading:3253716-Anticonvulsants,
pubmed-meshheading:3253716-Apomorphine,
pubmed-meshheading:3253716-Behavior, Animal,
pubmed-meshheading:3253716-Benzodiazepines,
pubmed-meshheading:3253716-Chemical Phenomena,
pubmed-meshheading:3253716-Chemistry,
pubmed-meshheading:3253716-Female,
pubmed-meshheading:3253716-Lethal Dose 50,
pubmed-meshheading:3253716-Male,
pubmed-meshheading:3253716-Mice,
pubmed-meshheading:3253716-Rats,
pubmed-meshheading:3253716-Reserpine,
pubmed-meshheading:3253716-Serotonin Antagonists,
pubmed-meshheading:3253716-Stereotyped Behavior
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pubmed:articleTitle |
Acyl derivatives of 1,5-benzodiazepines. III. Acyl derivatives of ethyl ester of 4-methyl-1H-tetrahydro-1,5-benzodiazepine-2-carboxylic acid.
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pubmed:affiliation |
Department of Technology of Drugs, Medical Academy, Wroc?aw, Poland.
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pubmed:publicationType |
Journal Article
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