Linked Life Data

3252584

Source:http://linkedlifedata.com/resource/pubmed/id/3252584

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-8-10
pubmed:abstractText
In a malariometric survey of 594 non-pregnant women living in 17 villages in Madang Province, Papua New Guinea, village groups were identified with average spleen rates of less than 35%, 40-49% and greater than or equal to 50%, with no difference in parasite rates between groups. Most villages where a non-Austronesian language was spoken had high spleen rates, but the association was not consistent. Some women were not indigenous to the study area and to control for the effects of migration on spleen rates, women were grouped according to their area of origin. This analysis, which cuts across village groups, identified 2 subpopulations, one with a high, and the other with a low spleen rate (relative risk 2.23; P less than 0.0001). Persistent splenomegaly was observed more frequently in the high spleen rate population (P less than 0.025) which also showed a significantly increased spleen size (P less than 0.01). The existence of 2 subpopulations living under the same conditions of malaria endemicity, but with different splenic responses to malaria, suggests an altered host immune response to malaria in the high spleen rate group. The absence of intermarriage between these two subpopulations indicates genetic differences distinguish them.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0035-9203
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
671-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
High and low spleen rates distinguish two populations of women living under the same malaria endemic conditions in Madang, Papua, New Guinea.
pubmed:affiliation
Papua New Guinea Institute of Medical Research, Madang.
pubmed:publicationType
Journal Article, Comparative Study