Linked Life Data

3251604

Source:http://linkedlifedata.com/resource/pubmed/id/3251604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-7-31
pubmed:abstractText
The interpeduncular nucleus (IPN) appears to be an important integrative center within the limbic system based on its extensive afferent and efferent connections and the presence of numerous neurotransmitters and peptides. Opiate receptors are present within particular subregions of IPN, which is one of the limbic structures showing an increase in regional glucose utilization (RGU) during withdrawal of morphine-addicted rats. The possible role of neural connections in withdrawal was studied by lesioning the main afferent pathway to IPN, the fasciculus retroflexus (FR) bilaterally. Four subnuclei of IPN, lateral, central, rostral and intermediate and FR showed significantly smaller increases in RGU during naloxone-induced withdrawal when compared to sham-operated controls. No difference was found in the apical, dorsal medial or dorsal lateral subnuclei. This metabolic effect of the lesions is not related in any simple way to the localization of opiate receptors or other neurochemical features of IPN. The lesioned animals also had greater weight loss due to diarrhea during withdrawal, consistent with IPN's presumed connection to the vagal nuclei. IPN appears to exhibit local and independent effects of FR lesions during opiate withdrawal.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
451
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Behavioral and metabolic alterations in the opiate withdrawal syndrome induced by lesions of fasciculus retroflexus.
pubmed:affiliation
Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.