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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1977-7-29
|
| pubmed:abstractText |
Functioning mononuclear cells have been harvested from heterotopic rat cardiac allografts during maximal transplant cellular infiltration. T cells, identified by a T cell-specific absorbed rabbit anti-rat brain serum, constituted two-thirds of the total cells recovered. Approximately 20% of the infiltrating cells bear and synthesize surface immunoglobulin. Macrophages, identified by latex ingestion and morphologic and cytochemical techniques, comprise 9% of the graft infiltrate. Donor-specific cytotoxic T lymphocytes are concentrated within the graft. A separate population of Fc receptor-positive recovered cells mediate antibody-dependent LMC (Ab-LMC). Neither effector cell was adherent or phagocytic. These studies have conclusively established that cytotoxic T lymphocytes accumulate within rejecting allografts; however, the enriched presence of cytotoxic T cells within the grafts is not fully dependent upon antigen recognition per se, since Lew animals grafted with both BN and BUF hearts have Lew anti-BN and Lew anti-BUF killer cells in each graft.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2020-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:325134-Animals,
pubmed-meshheading:325134-Brain,
pubmed-meshheading:325134-Cell Adhesion,
pubmed-meshheading:325134-Cell Membrane,
pubmed-meshheading:325134-Cell Movement,
pubmed-meshheading:325134-Cell Separation,
pubmed-meshheading:325134-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:325134-Graft Rejection,
pubmed-meshheading:325134-Heart Transplantation,
pubmed-meshheading:325134-Immune Sera,
pubmed-meshheading:325134-Immunity, Cellular,
pubmed-meshheading:325134-Immunologic Techniques,
pubmed-meshheading:325134-Lymphocytes,
pubmed-meshheading:325134-Phagocytes,
pubmed-meshheading:325134-Rats,
pubmed-meshheading:325134-Rats, Inbred BN,
pubmed-meshheading:325134-Rats, Inbred BUF,
pubmed-meshheading:325134-Rats, Inbred Lew,
pubmed-meshheading:325134-Receptors, Antigen, B-Cell,
pubmed-meshheading:325134-Species Specificity,
pubmed-meshheading:325134-Time Factors,
pubmed-meshheading:325134-Transplantation, Homologous
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Cellular components of allograft rejection: identity, specificity, and cytotoxic function of cells infiltrating acutely rejecting allografts.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|