Linked Life Data

3248125

Source:http://linkedlifedata.com/resource/pubmed/id/3248125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-6-15
pubmed:abstractText
Three newly synthesized dopamine-dipeptide compounds (Gly-Pro-dopamide, Lys-Pro-dopamide, Z-Lys-Pro-dopamide) which should be cleft in vivo by the enzyme dipeptidyl peptidase IV (EC 3.4.14.5) were investigated as to their protective activity against hemorrhagic shock in rats. All three compounds increased significantly the survival times of animals, subjected to hemorrhage, in nearly the same manner as dopamine did. They also relaxed the blood vessels of isolated perfused rat kidneys pretreated with phenoxybenzamine. This activity demonstrates a vasodilation via dopaminergic receptors. Regarding the blood pressure increasing activity, mediated by excitation of alpha-receptors, Gly-Pro-dopamide was less potent than dopamine but affected blood pressure about four times longer than dopamine did. Lys-Pro-dopamide and Z-Lys-Pro-dopamide were nearly equieffective to dopamine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
895-900
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Circulatory activity of dopamine-dipeptide compounds.
pubmed:affiliation
Institute of Drug Research, Academy of Sciences of the GDR, Berlin-Friedrichsfelde.
pubmed:publicationType
Journal Article, In Vitro