Linked Life Data

3248109

Source:http://linkedlifedata.com/resource/pubmed/id/3248109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10-11
pubmed:dateCreated
1989-6-15
pubmed:abstractText
In the isolated rat gastric vascular bed, PAF dosedependently decreased the perfusion rate and increased the formation of cysteinyl-leukotrienes, TXB2 and 6-keto F1 alpha (measured by radioimmunoassay). Inhibition of cysteinyl-leukotrienes biosynthesis by NDGA or antagonism of cysteinyl-leukotrienes receptors by FPL 55712 did not prevent the PAF induced reduction of gastric flow. Inhibition of cyclooxygenase by indomethacin aggravated the PFA-induced reduction of flow, however in the later period of experiment. BN 552021 - the PAF receptor antagonist, completely prevented the release of cysteinyl-leukotrienes, TXB2 and 6-keto F1 alpha into perfusate, however was not able to prevent completely the PAF induced reduction of gastric flow. We conclude that the reduction of flow observed after PAF administration seems to be related rather to the vasocongestion induced by PAF itself.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S228-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Release of cysteinyl-leukotrienes is of minor importance in PAF induced reduction of perfusion rate in the gastric vascular bed.
pubmed:affiliation
Department of Pharmacology, Copernicus Academy of Medicine, Cracow, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't