Linked Life Data

3246571

Source:http://linkedlifedata.com/resource/pubmed/id/3246571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-6-9
pubmed:abstractText
Re-epithelialization of 40 iatrogenic cornea ulcers produced in rabbits with iodine vapour burn were studied after topical administration of Betagan, Betoptic or Timoptic. At 24 hours there was no statistical difference in the wound healing rates among all the treated animal groups. At 48 hours, all the drug-treated groups were significantly different from the control group (p less than 0.05). There was no difference between the Betagan and Betoptic treated groups but the Timoptic-treated group was slower (p less than 0.05) than the Betoptic treated group, while the difference between the Timoptic and Betagan treated groups is not significant. At 72 hours the re-epithelialization rate of the Timoptic treated group was significantly slower than both the Betagan and Betoptic treated groups (p less than 0.05). By the 16th day following ulceration SEM examination revealed the Timoptic treated group had extensive epithelial cell desquamation, as well as hole formation and plasma membrane disruption. The Betagan treated corneas had mild superficial epithelial changes with loss of microvilli or slight desquamation. The Betoptic treated corneas were completely healed. In conclusion, Betagan is less toxic than Timoptic. Betoptic is the least toxic of the three drugs to regenerating rabbit corneal epithelium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
8756-3320
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Toxic effects of topically administered Betagan, Betoptic, and Timoptic on regenerating corneal epithelium.
pubmed:affiliation
Department of Ophthalmology, University of Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't