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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1989-6-2
|
| pubmed:abstractText |
In order to study noradrenaline-induced regulation of alpha- and beta-adrenoceptors, groups of male New Zealand White rabbits (n = 8) were treated with intravenous noradrenaline (0.09 mumol/kg x h) or ascorbate (0.1%) for 10 days via osmotic minipumps implanted in the femoral vein, and the number of cardiac, lung and lymphocyte beta-adrenoceptors as well as renal and platelet alpha 2-adrenoceptors were determined. 1. The mean arterial blood pressure, heart rate and catecholamine levels were measured before commencing, and after 24 h and 10 days infusion. Circulating noradrenaline concentrations were elevated approximately 6-fold at 24 h and were sustained at these levels after 10 days administration of noradrenaline. There were no significant alterations in the blood pressure while a significant decrease in the heart rate was observed at 24 h. 2. Alpha 2-adrenoceptor density was assessed using [3H]-yohimbine. A significant decrease in the number of alpha 2-adrenoceptors in the kidney was observed following the 10 days infusion with noradrenaline. This down-regulation was in marked contrast to the lack of alteration in platelet alpha 2-adrenoceptor number and the platelet alpha 2-adrenoceptor mediated aggregatory response. 3. The density of beta-adrenoceptors in lymphocytes, heart and lung were quantified using (-)[125I]iodocyanopindolol (ICYP). The noradrenaline infusions caused significant reductions in beta-adrenoceptor number in the heart and lung (containing predominantly beta 1-adrenoceptors) but not in lymphocytes (possessing mainly beta 2-adrenoceptors). The KD-values (pM) for ICYP binding to heart and lung were also significantly decreased in the present studies.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0028-1298
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
338
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
517-22
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3244394-Animals,
pubmed-meshheading:3244394-Blood Platelets,
pubmed-meshheading:3244394-Heart,
pubmed-meshheading:3244394-Hemodynamics,
pubmed-meshheading:3244394-Infusions, Intravenous,
pubmed-meshheading:3244394-Kidney,
pubmed-meshheading:3244394-Lung,
pubmed-meshheading:3244394-Lymphocytes,
pubmed-meshheading:3244394-Male,
pubmed-meshheading:3244394-Norepinephrine,
pubmed-meshheading:3244394-Platelet Aggregation,
pubmed-meshheading:3244394-Rabbits,
pubmed-meshheading:3244394-Receptors, Adrenergic,
pubmed-meshheading:3244394-Time Factors
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Regulation of adrenergic receptor number following chronic noradrenaline infusion in the rabbit.
|
| pubmed:affiliation |
University Department of Materia Medica, Stobhill General Hospital, Glasgow, United Kingdom.
|
| pubmed:publicationType |
Journal Article
|