Linked Life Data

3244329

Source:http://linkedlifedata.com/resource/pubmed/id/3244329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-5-26
pubmed:abstractText
The goal of this study was to determine if active tone and arteriolar constriction in response to increased PO2 are enhanced in the mesenteric microcirculation of spontaneously hypertensive rats (SHR) relative to normotensive Wistar-Kyoto (WKY) controls. Diameters of arterioles, metarterioles, and precapillary arterioles were measured in the mesoappendix of anesthetized 12-15 week old SHR and WKY rats during superfusion with physiological salt solution equilibrated with either 0%, O2, 5% O2 or 10% O2, with 5% CO2-balance N2. Active tone was assessed by superfusion with 10(-4) M adenosine. Metarterioles of SHR constricted significantly more than those of WKY when superfusion solution PO2 was elevated, but vessel closure did not occur in response to elevated PO2 in either SHR or WKY. Arteriolar dilation in response to 10(-4) M adenosine was not significantly different in hypertensive and normotensive animals, suggesting that resting tone is not elevated in mesoappendix arterioles of SHR. Although metarterioles of SHR constricted significantly more than those of WKY in response to elevated PO2, an enhanced response of arterioles to increased oxygen availability does not appear to contribute to functional rarefaction (i.e., active vessel closure) of small arterioles in the mesenteric microcirculation of SHR.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0740-9451
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Active tone and arteriolar responses to increased oxygen availability in the mesoappendix of spontaneously hypertensive rats.
pubmed:affiliation
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't