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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-6-5
|
| pubmed:abstractText |
Busulfan kinetics were studied in the rat plasma and brain after an I.P. dose of 14C-busulfan or busulfan (15 mg/kg). The distribution of busulfan to the brain was rapid and the ratio brain/plasma concentration was 0.74 during the time-course of busulfan. The elimination half-lives in plasma and brain were 3h for intact busulfan and 8h for the 14C-radioactivity. The radioactivity remaining in plasma and brain after 24h was mostly busulfan metabolites e.g. sulfolane, 3-hydroxysulfolane and tetrahydrothiophene-1-oxide as identified by gas chromatography-mass spectrometry. The protein binding to rat plasma was low (9.2 +/- 4.4%).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0378-7966
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
301-5
|
| pubmed:dateRevised |
2011-2-2
|
| pubmed:meshHeading |
pubmed-meshheading:3243326-Animals,
pubmed-meshheading:3243326-Blood Proteins,
pubmed-meshheading:3243326-Brain,
pubmed-meshheading:3243326-Busulfan,
pubmed-meshheading:3243326-Male,
pubmed-meshheading:3243326-Protein Binding,
pubmed-meshheading:3243326-Rats,
pubmed-meshheading:3243326-Rats, Inbred Strains
|
| pubmed:articleTitle |
Pharmacokinetic and metabolic studies of busulfan in rat plasma and brain.
|
| pubmed:affiliation |
Karolinska Pharmacy, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article
|