Linked Life Data

3241280

Source:http://linkedlifedata.com/resource/pubmed/id/3241280

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-5-18
pubmed:abstractText
Verapamil, a calcium-entry blocker, and sodium nitroprusside, a non-specific vasodilator, were infused into the blood-perfused hindlimbs of New Zealand genetically hypertensive rats (NZGH) and spontaneously hypertensive rats (SHR), two genetic models of hypertension, and their normotensive controls, New Zealand normotensive rats and Wistar-Kyoto rats (WKY). Vasodilator responses, measured as the falls in perfusion pressure from the initial values, were similar and increased in NZGH and SHR. The responses were strongly dependent on the initial level of perfusion pressure in each strain of rat. It is concluded that increased vascular resistance, rather than a qualitative difference in vasodilator mechanisms, accounts for the enhanced responses to verapamil and sodium nitroprusside in NZGH and SHR hindlimbs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S681-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effect of verapamil and sodium nitroprusside on hindlimb vascular resistance in New Zealand genetically hypertensive and Japanese spontaneously hypertensive rats.
pubmed:affiliation
Wellcome Medical Research Institute, University of Otago Medical School, Dunedin, New Zealand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't