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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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pubmed:dateCreated |
1989-5-16
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pubmed:abstractText |
A model is described for the binding of non-steroidal inhibitors of aromatase to the enzyme with interaction of a ligand with the Fe3+-haem of the cytochrome. The model suggests that the inhibitors utilise a common binding site with ring A of the steroidal substrates.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
8755-5093
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
215-29
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3241182-Androstenedione,
pubmed-meshheading:3241182-Aromatase Inhibitors,
pubmed-meshheading:3241182-Binding Sites,
pubmed-meshheading:3241182-Cholesterol Side-Chain Cleavage Enzyme,
pubmed-meshheading:3241182-Computer Simulation,
pubmed-meshheading:3241182-Female,
pubmed-meshheading:3241182-Humans,
pubmed-meshheading:3241182-Kinetics,
pubmed-meshheading:3241182-Models, Molecular,
pubmed-meshheading:3241182-Molecular Conformation,
pubmed-meshheading:3241182-Molecular Structure,
pubmed-meshheading:3241182-Placenta,
pubmed-meshheading:3241182-Pregnancy,
pubmed-meshheading:3241182-Structure-Activity Relationship
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|
pubmed:year |
1988
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|
pubmed:articleTitle |
Structure-activity relationships for non-steroidal inhibitors of aromatase.
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pubmed:affiliation |
Welsh School of Pharmacy, Cardiff, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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