Linked Life Data

3239889

Source:http://linkedlifedata.com/resource/pubmed/id/3239889

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-5-3
pubmed:abstractText
Chronic administration of bombesin in the adult rat affects cell growth and enzyme activities in the pancreas. It also induces hyperplasia of the fundic mucosa, increases antral gastrin content, and stimulates gastrin cell proliferation in the antral mucosa. These effects could be explained by the release of hormones such as gastrin and CCK, whose trophic roles on the digestive tract are well proven. Some arguments raise the possibility that bombesin may also act directly on these organs (i.e., the presence of specific receptors for bombesin, pancreatic changes induced by bombesin and not blocked by a potent, specific CCK receptor antagonist). It may well be that both mechanisms exist simultaneously. In addition, bombesin has a growth-promoting effect on the gastric mucosa and pancreas of suckling rats when administered either subcutaneously or orogastrically. Keeping in mind that the maternal milk contains a bombesin-like immunoreactant peptide, we consider that the latter finding raises questions about the possible physiological role of such a peptide in the regulation of the postnatal development of the gastrointestinal tract.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
547
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-67
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Influence of bombesin on gastrointestinal and pancreatic cell growth in adult and suckling animals.
pubmed:affiliation
Unité 10 INSERM de Gastroentérologie, Vieil Hôpital Bichat, Paris, France.
pubmed:publicationType
Journal Article