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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5-6
|
pubmed:dateCreated |
1977-6-22
|
pubmed:abstractText |
46 ambulatory patients with chronic lymphocytic leukemia were treated with Prednimustine either continuously (daily or each other day 20 mg) or intermittently (daily 20 mg for 14 days, followed by a pause of 4 weeks). A good response was seen in 28 patients lasting up to 17 + months (mean 4,5 + months) after terminating therapy. Patients without prior chemotherapy have improved earlier and to a smaller amount of the total dose applicated. Signes of bone marrow toxicity (anaemia, thrombocytopenia) were observed in 8 cases, gastrointestinal side effects in 7 cases, cutaneous exanthema in 3 cases, and one patient exhibited a severe stomatitis after treatment. Prednimustine constitutes an effective drug for chronic lymphatic leukemia.
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pubmed:language |
ger
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0377-2004
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
155-9
|
pubmed:dateRevised |
2008-2-28
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pubmed:meshHeading |
pubmed-meshheading:323777-Adult,
pubmed-meshheading:323777-Aged,
pubmed-meshheading:323777-Chlorambucil,
pubmed-meshheading:323777-Clinical Trials as Topic,
pubmed-meshheading:323777-Drug Combinations,
pubmed-meshheading:323777-Drug Evaluation,
pubmed-meshheading:323777-Female,
pubmed-meshheading:323777-Gingivitis, Necrotizing Ulcerative,
pubmed-meshheading:323777-Humans,
pubmed-meshheading:323777-Leukemia, Lymphoid,
pubmed-meshheading:323777-Male,
pubmed-meshheading:323777-Middle Aged,
pubmed-meshheading:323777-Nausea,
pubmed-meshheading:323777-Prednisolone
|
pubmed:year |
1977
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pubmed:articleTitle |
[Effect of Prednimustine (Leo 1031) in chronic lymphatic leukemia].
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract
|