Linked Life Data

3236936

Source:http://linkedlifedata.com/resource/pubmed/id/3236936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1989-5-11
pubmed:abstractText
3H-Quinuclidinyl benzylate (3H-QNB) and 3H-cis-methyldioxolane (3H-CD) binding to cholinergic muscarinic receptors have been carried out on the same membrane preparation from the rat brain cortex. Inhibition of 3H-QNB and 3H-CD binding by cholinergic muscarinic agonists and antagonists has been studied with determination of the IC50 values for each ligand. Antagonists were as potent at inhibiting 3H-QNB binding as 3H-CD binding. Muscarinic agonists were much less potent at inhibiting 3H-QNB binding than 3H-CD binding. The ratio of the IC50 values for the inhibition of the binding of 3H-QNB and 3H-CD was between 1 and 10 for antagonists and between 500 and 5000 for agonists. It is suggested that the determination of this ratio predicts agonist or antagonist activity of unknown compounds and represents a useful tool for their screening.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
619-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Potency ratio for the inhibition of 3H-QNB and 3H-cis-methyldioxolane binding predicts agonist or antagonist activity on muscarinic receptors.
pubmed:affiliation
Department of Biochemical Pharmacology, Centre de Recherche Pierre Fabre, Castre, France.
pubmed:publicationType
Journal Article, In Vitro