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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-4-28
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pubmed:abstractText |
The effect of the nephrotic syndrome induced by puromycin aminonucleoside (PA) in rats on specific antibody responses to 2,4 dinitrophenyl (DNP) conjugated to either spider crab haemocyanin (MSH), a T cell-dependent antigen, or hydroxyethyl starch (HES), a T cell-independent type 2 antigen were studied. The serum IgG anti-DNP levels following immunization with both antigens were reduced in nephrotic animals compared with controls while IgM anti-DNP antibody titres were higher. The half-life of IgG anti-DNP antibodies passively transferred into non-immunized nephrotic rats was markedly reduced while the half-life of anti-DNP antibodies of the IgM class was comparable to that in controls. Low serum IgG and elevated IgM levels were seen in nephrotic animals compared to controls. Antibody-forming cells specific for DNP were demonstrated by immunohistology on rat spleens and the numbers of both IgG and IgM-producing cells were found to be significantly increased (P less than 0.05) in nephrotic animals in response to both DNP-HES and DNP-MSH. These data indicate that in nephrotic rats the alteration seen in the serum immunoglobulin levels is not attributable to reduced antibody production but increased catabolism of serum IgG antibodies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-101595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-1079322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-13999512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-14450081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-18885493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-2408798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-26723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-3514239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-3878244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-4560341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-5685368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-6156981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-6170000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-6347472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-6444638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-6601737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-7140027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3233791-7238567
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3233791-Agammaglobulinemia,
pubmed-meshheading:3233791-Animals,
pubmed-meshheading:3233791-Antibody-Producing Cells,
pubmed-meshheading:3233791-Dinitrobenzenes,
pubmed-meshheading:3233791-Half-Life,
pubmed-meshheading:3233791-Immunoglobulin A,
pubmed-meshheading:3233791-Immunoglobulin G,
pubmed-meshheading:3233791-Immunoglobulin M,
pubmed-meshheading:3233791-Male,
pubmed-meshheading:3233791-Nephrosis, Lipoid,
pubmed-meshheading:3233791-Puromycin Aminonucleoside,
pubmed-meshheading:3233791-Rats,
pubmed-meshheading:3233791-Rats, Inbred Strains,
pubmed-meshheading:3233791-Spleen
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pubmed:year |
1988
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pubmed:articleTitle |
Hypogammaglobulinaemia in nephrotic rats is attributable to hypercatabolism of IgG.
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pubmed:affiliation |
Department of Nephrology, Queen Elizabeth Hospital, Birmingham.
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pubmed:publicationType |
Journal Article
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