Linked Life Data

3233495

Source:http://linkedlifedata.com/resource/pubmed/id/3233495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-5-10
pubmed:abstractText
The tail-flick response of adult male CD-1 mice was used to assess the analgesic properties of restraint alone and in combination with morphine during the diurnal and nocturnal periods. Mice were restrained in conical metal devices that allowed a change in position from supine to prone but not from front to back. Restraint induced an analgesia equipotent to a 2.5 mg/kg dose of morphine within 0.5 h of its initiation. Although habituation occurred over the restraint period a pronounced analgesia was still evident at the end of the 3 h test period. The habituation to restraint-induced analgesia was more rapid at night. Although the basal tail-flick latency to thermal stimulation was decreased during the nocturnal period the time of day did not alter the degree of analgesia induced by either restraint or morphine. Morphine induced a dose- and time-dependent analgesia during both the diurnal and nocturnal periods and this analgesia was potentiated by restraint stress only during the nocturnal period. Naloxone at high doses (10.0 or 20.0 mg/kg) blocked the analgesia induced by morphine but did not totally block the analgesia induced either by restraint or morphine plus restraint. These data suggest the potentiation of an opiate effect by stress may depend on habituation or tolerance to the stressor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
473
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-35
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Restraint-induced analgesia in the CD-1 mouse: interactions with morphine and time of day.
pubmed:affiliation
Developmental and Cell Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
pubmed:publicationType
Journal Article