Linked Life Data

3230567

Source:http://linkedlifedata.com/resource/pubmed/id/3230567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1989-4-20
pubmed:abstractText
Serum autoantibodies to cartilage cell surface proteins have been detected in the blood from patients with osteoarthritis (OA) and rheumatoid arthritis (RA). As tested by ELISA using plasma membrane vesicles as a substrate, patients with RA exhibited significantly elevated antibody titers, whereas titers were somewhat lower in OA, and only marginal in controls. The antibodies did not crossreact with plasma membranes from fibroblasts or epithelial cells, but showed interspecies crossreactivity towards chicken and rat cartilage cell surface proteins. A group of at least 9 distinct immunoreactive polypeptides could be characterized by Western blot analysis. These peptides had molecular weights of Mr28, 30, 38, 42, 66, 76, 78, 116, and 155 kD. The patients each expressed an individual pattern of reactive antibodies against these proteins. Autoantibody reactivity to cell surface associated collagen type II was also observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0315-162X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1811-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Serum antibodies against chondrocyte cell surface proteins in osteoarthritis and rheumatoid arthritis.
pubmed:affiliation
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, FRG.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't