Linked Life Data

3229733

Source:http://linkedlifedata.com/resource/pubmed/id/3229733

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-4-20
pubmed:abstractText
Nineteen type I diabetics and 15 healthy subjects were given 500 ml of a mixed liquid test meal (flüssige Diabetikerkost, Fresenius, FRG) orally. Furthermore, heart rate variation during deep breathing and Valsalva maneuver was performed in order to test vagus nerve function. PP serum levels were determined before, and 2 to 160 minutes after finishing, the meal. In healthy subjects and in 10 diabetics without any sign of autonomic neuropathy of the vagus nerve a significant rise in PP serum values after the meal could be detected. In 7 type I diabetics with autonomic cardiac neuropathy (abnormal beat-to-beat variation during deep breathing and during the Valsalva maneuver) post-prandial PP levels remained low. Two diabetics without autonomic neuropathy were excluded from the test because endogenic PP antibodies were found in their serum. PP secretion after ingestion of a mixed protein-rich meal is mostly mediated by the vagus nerve or by the extravagal cholinergic system. After vagotomy, no PP secretion after a mixed meal could be detected. Measuring PP serum levels in diabetics after a mixed meal can be useful to check vagus nerve function in the gastrointestinal tract in order to detect autonomic neuropathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0172-6390
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-41
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Pancreatic polypeptide (PP) response to food in type I diabetics with and without diabetic autonomic neuropathy.
pubmed:affiliation
Medical University Clinic, Department B, Westfälische Wilhelms-Universität Münster, FRG.
pubmed:publicationType
Journal Article