Linked Life Data

3228626

Source:http://linkedlifedata.com/resource/pubmed/id/3228626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-4-20
pubmed:abstractText
We measured the levels of trypsin-releasable spasmogenic substances (TRSS) in the plasma of spontaneously hypertensive rats (SHR) during the development of hypertension. TRSS levels (means +/- SEM, N = 4) were significantly higher at 12 weeks (7.13 +/- 1.05 micrograms bradykinin equivalents (BKE)/ml plasma) and 24 weeks (6.87 +/- 0.60 micrograms BKE/ml) compared to 8 weeks (3.3 +/- 0.55 micrograms BKE/ml) and to normotensive Wistar Kyoto (WKN) rats, whose levels were 3.74 +/- 0.74 micrograms BKE/ml at 24 weeks and did not change significantly during the period studied. The mean arterial pressure (MAP) of SHR was 150-170, 160-180 and 170-220 mmHg at 8, 12 and 24 weeks, respectively, whereas the WKN MAP was 110-120 mmHg at 24 weeks. The increase in total TRSS was due to substances which elicit the slow contraction of the isolated guinea pig ileum and which could be distinguished from BK, T-kinin and other BK homologues by gel filtration on Sephadex G-25, gradient elution chromatography on CM-cellulose and by the slow rate of contraction of the guinea pig ileum. All of these properties are the same as those we have previously demonstrated for TRSS of Goldblatt 1-kidney 1-clip renal hypertensive rats and which are due, at least in part, to a 14 amino acid peptide whose composition does not correspond to any known spasmogenic substance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
New trypsin-releasable spasmogenic substances in the plasma of spontaneously hypertensive rats.
pubmed:affiliation
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't