Linked Life Data

3226726

Source:http://linkedlifedata.com/resource/pubmed/id/3226726

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-28
pubmed:abstractText
To assess the erythroproliferative effects of a variety of retroviruses in vitro, hemopoietic precursors were incubated with the viruses then plated in methylcellulose. Only replication defective transforming viruses were active in this assay and produced colonies of erythroid cells. The effective transforming viruses were: Friend virus and viruses containing the abl, fes, src, Ha-ras, Ki-ras, bas, raf, raf/myc, erb B and cbl oncogenes. Replication competent viruses and those bearing the myc, myb and fos oncogenes were unable to initiate colony formation. Significant differences were observed in the colonies induced by several of the transforming genes based on (i) colony size, (ii) morphology, (iii) time course of development and (iv) sensitivity to erythropoietin. The oncogene-expressing retroviruses appeared to have the same target cell, which may be less differentiated erythroid precursor than the target cell for Friend virus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0890-6467
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Erythroproliferation in vitro can be induced by abl, fes, src, ras, bas, raf, raf/myc, erb B and cbl oncogenes but not by myc, myb and fos.
pubmed:affiliation
Laboratory of Experimental Carcinogenesis and Immunopathology, National Institutes of Health, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't