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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1989-4-5
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pubmed:abstractText |
A high-performance liquid chromatographic (HPLC) assay for isosorbide dinitrate in pharmaceutical formulations is described. The method employs a reversed-phase C18 column with a mobile phase containing methanol/water/acetate buffer and is specific for isosorbide dinitrate with respect to its 2- and 5-mononitrate degradation products and other organic polynitrate esters. The method is applicable to the analysis of the diluted bulk drug and dosage forms, including sublingual, oral, chewable, and timed-release preparations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9665
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
574-8
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading | |
pubmed:year |
1988
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pubmed:articleTitle |
Determination of isosorbide dinitrate in pharmaceutical products by HPLC.
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pubmed:affiliation |
U.S. Food and Drug Administration, Pharmaceutical Analysis Section, Minneapolis, Minnesota 55401.
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pubmed:publicationType |
Journal Article
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