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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1989-3-29
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pubmed:abstractText |
The pathological basis for dementia in Lewy body disease (LBD) remains controversial. While some investigators propose that cortical lesions are responsible, others favor a subcortical basis for this dementia. Brains from 35 patients with LBD (11 demented with diffuse LBD; 12 demented and 12 non-demented with a brainstem type of LBD) were clinicopathologically examined to elucidate the pathological differences between demented and non-demented patients with LBD. In cases of diffuse LBD, the cortical lesions were found to be responsible for the dementia. In some of the cases (25%) with the brainstem type of LBD, the dementia was attributed to an Alzheimer pathology, while in many cases (75%), degeneration in the subcortical nuclei, mainly the nucleus basalis of Meynert, played a major role in the dementia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
0722-5091
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-305
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3224472-Aged,
pubmed-meshheading:3224472-Aged, 80 and over,
pubmed-meshheading:3224472-Brain Diseases,
pubmed-meshheading:3224472-Brain Stem,
pubmed-meshheading:3224472-Cytoplasmic Granules,
pubmed-meshheading:3224472-Dementia,
pubmed-meshheading:3224472-Female,
pubmed-meshheading:3224472-Humans,
pubmed-meshheading:3224472-Male,
pubmed-meshheading:3224472-Middle Aged
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pubmed:articleTitle |
Lewy body disease with and without dementia: a clinicopathological study of 35 cases.
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pubmed:affiliation |
Psychiatric Research Institute of Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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