Linked Life Data

3220864

Source:http://linkedlifedata.com/resource/pubmed/id/3220864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-3-17
pubmed:abstractText
Fluid administered during resuscitation translocates beneath the burn wound and is considered inert "third space" loss. This study was done to determine whether subeschar tissue fluid (STF) functions as an immunobiologic reservoir. Seven patients with a mean BSA burn of 55% underwent isotonic volume resuscitation and burn treatment with low penetration topical agents. STF was collected at the time of fascial excision. Chemical analysis of STF was similar to serum; bacterial cultures grew no organisms. Ten percent dilutions of STF and burn serum significantly blunted mitogen-induced blastogenic response compared to control serum. STF was significantly more suppressive than burn serum (P less than .03). Conclusions: 1. STF may act as both an immunologic barrier to microbial clearance in otherwise viable subcutaneous tissue and a reservoir for systemically reabsorbed immunosuppressive factors. 2. In addition to removing dead tissue, fascial excision may prove beneficial because it removes large amounts of immunosuppressive STF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0273-8481
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
584-8
pubmed:dateRevised
2006-8-15
pubmed:meshHeading
pubmed:articleTitle
The suppressive effect of subeschar tissue fluid upon in vitro cell-mediated immunologic function.
pubmed:affiliation
Department of Surgery, University of South Alabama, Mobile 36688.
pubmed:publicationType
Journal Article