Linked Life Data

3220773

Source:http://linkedlifedata.com/resource/pubmed/id/3220773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-3-14
pubmed:abstractText
Four cases of primary non-Hodgkin's lymphoma (NHL) of the thyroid were studied using flow cytometric (FCM) DNA analysis of propidium iodide-stained nuclei retrieved from formalin-fixed, paraffin-embedded tissue. Two of the four cases were aneuploid and two were euploid. In the two euploid cases, both patients are alive and without evidence of recurrent disease after an average of 4 years follow-up. Of the two aneuploid cases, one patient is alive and free of recurrent disease after 1 year. In the other aneuploid case, the patient died of disseminated disease 8 months after presentation despite having a low-grade (follicular, predominantly small cleaved cell type) and low-stage (tumor confined to thyroid at presentation) lymphoma. These data suggest that the DNA ploidy of primary NHL of the thyroid can be determined using fixed, paraffin-embedded tissue. Our results also suggest that a large study to assess the prognostic value of this technique is warranted.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-6403
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
324-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Flow cytometric analysis of DNA ploidy in lymphomas of the thyroid.
pubmed:affiliation
Department of Pathology, University of North Carolina, Chapel Hill 27599-7525.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't