Linked Life Data

3219749

Source:http://linkedlifedata.com/resource/pubmed/id/3219749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-3-17
pubmed:abstractText
Ciprofloxacin is a broad-spectrum antibiotic orally active against both gram-positive and gram-negative bacteria. Recent literature indicates that orally administered activated charcoal can alter the bioavailability of many drugs and in vitro studies have demonstrated an interaction with ciprofloxacin. To evaluate in vivo the effects of activated charcoal on ciprofloxacin pharmacokinetics, six healthy volunteers received, according to a cross-over design, either ciprofloxacin 500 mg alone or concomitantly 1 g activated charcoal. The coadministration of the latter drug did not influence any of the considered pharmacokinetic parameters. Activated charcoal at a clinically effective dose, therapeutically used in gaseousness, does not alter ciprofloxacin pharmacokinetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0392-906X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of orally administered activated charcoal on ciprofloxacin pharmacokinetics in healthy volunteers.
pubmed:affiliation
Division of Infectious Diseases, Regional Hospital and Foundation E. and S. Macchi, Varese, Italy.
pubmed:publicationType
Journal Article