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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1989-3-16
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pubmed:abstractText |
Catecholamines are hypothesized to control cellular development in the central nervous system. In the current study, isoproterenol administered intracisternally to neonatal rats was found to inhibit DNA synthesis [( 3H]thymidine incorporation) in brain regions. The regional selectivity of effect corresponded to the sequence of cellular maturation, namely midbrain + brainstem greater than cerebral cortex greater than cerebellum, suggesting that the specific linkage of beta-adrenergic receptors to cessation of cell replication occurs during a specific maturational stage.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0361-9230
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3219605-Adrenergic Fibers,
pubmed-meshheading:3219605-Animals,
pubmed-meshheading:3219605-Brain,
pubmed-meshheading:3219605-Cell Differentiation,
pubmed-meshheading:3219605-Cell Division,
pubmed-meshheading:3219605-DNA Replication,
pubmed-meshheading:3219605-Isoproterenol,
pubmed-meshheading:3219605-Rats,
pubmed-meshheading:3219605-Rats, Inbred Strains,
pubmed-meshheading:3219605-Thymidine
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pubmed:year |
1988
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pubmed:articleTitle |
Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.
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pubmed:affiliation |
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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