Linked Life Data

3219580

Source:http://linkedlifedata.com/resource/pubmed/id/3219580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-3-23
pubmed:abstractText
The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and thereafter continued to increase to the adult level. The partial purification of stable-tubule-only polypeptide (STOP) from the supernatant showed that high amounts of this protein exist at all ages, especially in young animals. The age-related increase in the microtubule cold-stabilizing activity of the cerebrum supernatant resulted from a developmental decrease in factors inhibiting STOP activity. The present study shows that (1) a close temporal correlation exists between the in vitro and in situ acquisition of cold-stable microtubules during brain development, (2) STOP activity may account for this acquisition, and (3) STOP activity is controlled by inhibiting factors that decrease with age, in turn allowing increased stability of the microtubular apparatus, a necessary condition for the development of neuronal processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
470
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-204
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Developmental study of factors controlling microtubule in vitro cold-stability in rat cerebrum.
pubmed:affiliation
C.N.R.S. UA 1197, Laboratoire de Neurobiologie Endocrinologique, Université des Sciences et Techniques du Languedoc Montpellier, France.
pubmed:publicationType
Journal Article