Linked Life Data

3217469

Source:http://linkedlifedata.com/resource/pubmed/id/3217469

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-3-8
pubmed:abstractText
The bulk biodistribution of a trifluorinated neuroleptic (fluphenazine) was studied using 19F magnetic resonance imaging (MRI). Fifteen male Sprague-Dawley rats were injected with fluphenazine (120 mg/kg) and scanned in a G.E. CSI 2.0 tesla MRI system. The rats were killed following scanning and the brains were removed. The excised brains were then scanned using 1H and 19F MR techniques. The fluorinated neuroleptic was imaged at the injection site, spectroscopically detected in vivo in the head, and spectroscopically localized in the whole brain. These data suggest that in vivo 19F MRI of fluorinated agents is possible and could have clinical and research applications to the neurosciences.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
19F magnetic resonance imaging and spectroscopy of a fluorinated neuroleptic ligand: in vivo and in vitro studies.
pubmed:affiliation
Nancy Pritzker Laboratory of Behavioral Neurochemistry, Stanford University Medical School.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.