Linked Life Data

3213584

Source:http://linkedlifedata.com/resource/pubmed/id/3213584

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-2-14
pubmed:abstractText
Various natural protease inhibitors stimulate the proliferation of rat astrocytes grown in primary culture in the absence of serum. They are inactive on the proliferation of oligodendrocytes. The mean level of stimulation of the astrocyte proliferation elicited by the protease inhibitors is higher when the cells are in the growth phase, at low cell density than when they are quiescent, at high cell density. Among the protease inhibitors tested three serum proteins, alpha 1-antitrypsin, alpha 2-macroglobulin and anti-thrombin III were the most active. The present results, taken together with our previous finding that thrombin and some other proteases also stimulate the proliferation of astroglial cells but not of oligodendroglial cells, suggest that proteases and protease inhibitors participate, through still unclear mechanisms, in the control of the proliferation of astrocytes, but not in that of oligodendrocytes, during brain ontogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Proliferation of rat astrocytes, but not of oligodendrocytes, is stimulated in vitro by protease inhibitors.
pubmed:affiliation
Centre de Neurochimie du CNRS, Strasbourg, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't