Linked Life Data

3211983

Source:http://linkedlifedata.com/resource/pubmed/id/3211983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-2-23
pubmed:abstractText
Four food-deprived squirrel monkeys were trained to emit complex sequences of responses. The sequences involved pressing lighted response keys in orders dictated by colors that illuminated the keys, and ranged in length from two to five responses. Appropriate completion of these behavioral chains could be followed by food presentation. Acute administration of a range of doses (0.1-1.7 mg/kg) of cocaine hydrochloride produced dose-related decreases in the rate of completing chains and in accuracy of performance during chains. There was little evidence that the drug's effects on overall accuracy were related to the length of the chain. Three of the monkeys were exposed to daily administration of a large dose of cocaine, first after daily sessions and then prior to sessions. Daily postsession administration did not alter the dose-effect curves, but daily presession injection did, indicating the development of behavioral or "contingent" tolerance. In all cases, tolerance was accompanied by an increase in reinforcement frequency relative to the frequency observed following acute administration. Omission of the daily dose during presession drug administration resulted in performance near original control levels indicating essentially no withdrawal effect. The findings illustrate the importance of behavioral factors in the development of tolerance to cocaine in a primate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
737-48
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Behavioral tolerance to cocaine in squirrel monkeys: acute and chronic effects on complex operant behavior.
pubmed:affiliation
Psychology Department, University of Florida, Gainesville 32611.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.