Linked Life Data

3211499

Source:http://linkedlifedata.com/resource/pubmed/id/3211499

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-2-15
pubmed:abstractText
The dynamics of aqueous humor were studied before and after discontinuing timolol maleate in chronic users. Nineteen patients (mean length of treatment, 44 months) were studied by measuring their baseline intraocular pressure (IOP) and aqueous humor flow during treatment and 2 days to 6 weeks after discontinuing the drug. Flow did not increase significantly until 4 days after discontinuing timolol, and IOP did not increase significantly until 14 days later. Flow did not revert to its normal rate for 2 to 6 weeks. Intraocular pressure was 15% lower and the flow 24% lower during maintenance treatment than 1 month after discontinuing timolol. This comparison demonstrates the efficacy of chronic treatment. Recovery of aqueous flow is slow after stopping timolol. This finding suggests that lower or less frequent doses than are customarily used might be equally efficacious. If timolol is discontinued before filtration surgery, its effects will remain for 2 to 4 weeks.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0161-6420
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1212-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The effects of withdrawal of timolol in chronically treated glaucoma patients.
pubmed:affiliation
Mayo Clinic, Rochester, Minnesota 55905.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't