Linked Life Data

3210065

Source:http://linkedlifedata.com/resource/pubmed/id/3210065

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1989-2-13
pubmed:abstractText
End-stage renal disease (ESRD) is strongly associated with both hypertension and diabetes. As both diabetes and hypertension tend to be familial, we hypothesized a familial clustering of ESRD cases. Using 114 cases from three dialysis centers and 99 controls, the exposure odds ratio was determined. Mantel-Haenszel analysis demonstrated that individual history of hypertension (ORmh = 5.14; 95% Cl = 2.29-11.56) and history of chronic renal failure in a first or second degree relative (chi 2mh = 5.12; p less than 0.05) were significant "risk" factors for being dialysed for ESRD, while family history of hypertension posed a more questionable risk (ORmh = 1.92 95% Cl 0.96-3.86). In fact, when the subset of patients identified with hypertensive renal disease was considered independently, the risk due to family history of hypertension increased 14-fold which suggests a role as a confounder for hypertensive renal disease. The effect of chronic renal failure in a relative was independent of family history of diabetes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0895-4356
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1189-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
A familial risk of chronic renal failure among blacks on dialysis?
pubmed:affiliation
Hypertension Center, Charles R. Drew Postgraduate Medical School, Los Angeles, CA 90059.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't