pubmed-article:320934 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:320934 | lifeskim:mentions | umls-concept:C0543467 | lld:lifeskim |
pubmed-article:320934 | lifeskim:mentions | umls-concept:C0003205 | lld:lifeskim |
pubmed-article:320934 | lifeskim:mentions | umls-concept:C0032893 | lld:lifeskim |
pubmed-article:320934 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
pubmed-article:320934 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:320934 | pubmed:dateCreated | 1977-4-30 | lld:pubmed |
pubmed-article:320934 | pubmed:abstractText | The use of antiseptics was reappraised because of the increasing problem of antibiotic-resistant bacteria. A formaldehyde (noxythiolin) and a halogen (povidone-iodine) were investigated, these being the most appropriate antiseptic groups. Povidone-iodine solution significantly reduced the mortality of mice (P less than 0.01) and rats (P less than 0.01) with peritonitis. Noxythiolin (1% and 0.5%) did not. Antiseptic irrigation of the rat colon before and after anastomosis resulted in significantly fewer 'poor' anastomoses (P less than 0.05) without inhibiting healing. Noxythiolin 2.5% and 1% significantly reduced peritoneal adhesion formation in rats, but a newly formulated povidone-iodine solution with increased polyvinylpyrrolidone content was superior to noxythiolin 1% and 0.5%. Povidone-iodine neither inhibited rat abdominal wound healing nor induced bacterial resistance. In 3 subsequent controlled clinical trials a dry-powder povidone-iodine formulation halved wound infection after grid-iron appendicectomy (P less than 0.025), reduced infection in elective 'clean' surgery, and significantly reduced infection after a wide variety of 'potentially contaminated' abdominal procedures (P less than 0.01). A return to the principles of Lister is advocated. | lld:pubmed |
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pubmed-article:320934 | pubmed:language | eng | lld:pubmed |
pubmed-article:320934 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:320934 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:320934 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:320934 | pubmed:month | Mar | lld:pubmed |
pubmed-article:320934 | pubmed:issn | 0035-8843 | lld:pubmed |
pubmed-article:320934 | pubmed:author | pubmed-author:GilmoreO JOJ | lld:pubmed |
pubmed-article:320934 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:320934 | pubmed:volume | 59 | lld:pubmed |
pubmed-article:320934 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:320934 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:320934 | pubmed:pagination | 93-103 | lld:pubmed |
pubmed-article:320934 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:320934 | pubmed:year | 1977 | lld:pubmed |
pubmed-article:320934 | pubmed:articleTitle | A reappraisal of the use of antiseptics in surgical practice. | lld:pubmed |
pubmed-article:320934 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:320934 | pubmed:publicationType | Clinical Trial | lld:pubmed |
pubmed-article:320934 | pubmed:publicationType | Review | lld:pubmed |
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