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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-4-30
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pubmed:abstractText |
The use of antiseptics was reappraised because of the increasing problem of antibiotic-resistant bacteria. A formaldehyde (noxythiolin) and a halogen (povidone-iodine) were investigated, these being the most appropriate antiseptic groups. Povidone-iodine solution significantly reduced the mortality of mice (P less than 0.01) and rats (P less than 0.01) with peritonitis. Noxythiolin (1% and 0.5%) did not. Antiseptic irrigation of the rat colon before and after anastomosis resulted in significantly fewer 'poor' anastomoses (P less than 0.05) without inhibiting healing. Noxythiolin 2.5% and 1% significantly reduced peritoneal adhesion formation in rats, but a newly formulated povidone-iodine solution with increased polyvinylpyrrolidone content was superior to noxythiolin 1% and 0.5%. Povidone-iodine neither inhibited rat abdominal wound healing nor induced bacterial resistance. In 3 subsequent controlled clinical trials a dry-powder povidone-iodine formulation halved wound infection after grid-iron appendicectomy (P less than 0.025), reduced infection in elective 'clean' surgery, and significantly reduced infection after a wide variety of 'potentially contaminated' abdominal procedures (P less than 0.01). A return to the principles of Lister is advocated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-1034491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-1174808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-1190682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-13311709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-13332267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-13356359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-13383770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-13478818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-14132621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-14150735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-235397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4133319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4253560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4352614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4364995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4540874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4577499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4706478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4797251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4824314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4835193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4902281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4913491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-4940229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5021550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5352638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5467147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-55590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5574715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5574716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-5638543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-811302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/320934-821972
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0035-8843
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-103
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:320934-Animals,
pubmed-meshheading:320934-Anti-Bacterial Agents,
pubmed-meshheading:320934-Anti-Infective Agents, Local,
pubmed-meshheading:320934-Clinical Trials as Topic,
pubmed-meshheading:320934-Drug Resistance,
pubmed-meshheading:320934-Guinea Pigs,
pubmed-meshheading:320934-Humans,
pubmed-meshheading:320934-Mice,
pubmed-meshheading:320934-Noxythiolin,
pubmed-meshheading:320934-Peritonitis,
pubmed-meshheading:320934-Povidone-Iodine,
pubmed-meshheading:320934-Rats,
pubmed-meshheading:320934-Surgical Wound Infection,
pubmed-meshheading:320934-Tissue Adhesions
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pubmed:year |
1977
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pubmed:articleTitle |
A reappraisal of the use of antiseptics in surgical practice.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Review
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