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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1989-2-21
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pubmed:abstractText |
In an analysis of a 90-kb region around the human beta-globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer-like elements of the beta-globin gene. SARs flanking the complex co-habit with the boundaries of the putative beta-like globin gene regulatory domain. In contrast, we have detected no SARs within a 140-kb region of the human alpha-globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-1202042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-16453673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2445400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-277332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2825132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2835225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2840282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2985625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-2987966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3002631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3015418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3032452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3039464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3430625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3478680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3551593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3551943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3595568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3627985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3690667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3719696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3732249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3763397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-3879975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-4001930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-4066658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-4214419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6088069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6091913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6200874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6200877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6205764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6275383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6652684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-6896344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-7105181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-825231
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3337-44
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:3208739-Binding Sites,
pubmed-meshheading:3208739-Blotting, Southern,
pubmed-meshheading:3208739-Cell Nucleus,
pubmed-meshheading:3208739-DNA,
pubmed-meshheading:3208739-Gene Expression Regulation,
pubmed-meshheading:3208739-Globins,
pubmed-meshheading:3208739-Humans,
pubmed-meshheading:3208739-Multigene Family,
pubmed-meshheading:3208739-Nucleic Acid Hybridization,
pubmed-meshheading:3208739-Restriction Mapping
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pubmed:year |
1988
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pubmed:articleTitle |
Nuclear scaffold attachment sites in the human globin gene complexes.
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pubmed:affiliation |
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
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pubmed:publicationType |
Journal Article
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