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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-2-22
|
| pubmed:abstractText |
Vasoactive intestinal polypeptide (VIP) has been shown to increase the amount of time spent in rapid-eye-movement (REM) sleep both in cats and in rats. In the present study we examined the effect of a newly available competitive VIP-antagonist ([4Cl-D-Phe6-Leu17]-VIP) on sleep-wake patterns in male rats during both the light and the dark phase of 24 h. Continuous intracerebroventricular application of this VIP-antagonist reduced by 44% the amount of time spent in REM sleep during the light period. It is concluded that VIP may play a role in the generation and maintenance of REM sleep.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
458
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
192-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3208098-Animals,
pubmed-meshheading:3208098-Cerebral Ventricles,
pubmed-meshheading:3208098-Injections, Intraventricular,
pubmed-meshheading:3208098-Rats,
pubmed-meshheading:3208098-Rats, Inbred Strains,
pubmed-meshheading:3208098-Reference Values,
pubmed-meshheading:3208098-Sleep, REM,
pubmed-meshheading:3208098-Vasoactive Intestinal Peptide
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat.
|
| pubmed:affiliation |
Netherlands Institute for Brain Research, Amsterdam.
|
| pubmed:publicationType |
Journal Article
|