Linked Life Data

320415

Source:http://linkedlifedata.com/resource/pubmed/id/320415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-4-15
pubmed:abstractText
Diarrhea can be defined as increased frequency of bowel movements (greater than 3 per day) plus decreased consistency of stools (volume greater than 200 ml per defecation). Two pathogenetic mechanisms have been intensively investigated and partially elucidated within the last years: 1. Secretion of electrolytes and water by way of induction of an augmented synthesis of cAMP in the mucosa cell. Cholera enterotoxin and other bacterial toxins as well as VIP (vasoactive intestinal peptide) cause diarrhea by this mechanism. 2. Certain substances such as dihydroxylated bile acids, diphenolic laxatives and probably fatty acids cause leakage of the tight junctions between mucosal cells and cause leakage of electrolytes and water back into the intestinal lumen.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0300-8622
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
[Current concepts in the pathophysiology of the diarrhea (author's transl)].
pubmed:publicationType
Journal Article, English Abstract, Review