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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1989-2-2
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pubmed:abstractText |
Newborn BALB/cCrgl female mice received five daily injections of various doses of diethylstilbestrol (DES), 0.0001-10 micrograms. Mice were killed at 6 days of age or at 4 months after ovariectomy at 40-42 days. Subepithelial nodules of polygonal cells in the upper (Mullerian) vagina during early postnatal life were associated with the later occurrence of ovary-independent persistent stratification with or without cornification in mice treated neonatally with 0.1-10 micrograms DES and thus are a possible predictor of this phenomenon. The thresholds for the induction of ovary-independent epithelial pegs, downgrowths and adenosis (glandular formations) were 0.1 microgram and 0.5 microgram DES/day, respectively.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
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pubmed:issn |
0304-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-14
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3203338-Age Factors,
pubmed-meshheading:3203338-Animals,
pubmed-meshheading:3203338-Animals, Newborn,
pubmed-meshheading:3203338-Diethylstilbestrol,
pubmed-meshheading:3203338-Epithelium,
pubmed-meshheading:3203338-Female,
pubmed-meshheading:3203338-Mice,
pubmed-meshheading:3203338-Mice, Inbred BALB C,
pubmed-meshheading:3203338-Ovariectomy,
pubmed-meshheading:3203338-Vagina
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pubmed:year |
1988
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pubmed:articleTitle |
Vaginal abnormalities in ovariectomized BALB/cCrgl mice after neonatal exposure to different doses of diethylstilbestrol.
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pubmed:affiliation |
Department of Zoology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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