Linked Life Data

3201243

Source:http://linkedlifedata.com/resource/pubmed/id/3201243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4885
pubmed:dateCreated
1989-1-25
pubmed:abstractText
Severe heat shocks block the splicing of intervening sequences from messenger RNA precursors. The RNA's that accumulate after a severe heat shock have normal transcription start sites and are uncut at both their 5' and 3' splice junctions. Some of these unspliced transcripts leave the nucleus and enter the pool of cytoplasmic messenger RNA. Translation of these RNA's proceeds into their intervening sequences, resulting in the production of abnormal proteins. Thus, the repression of normal transcription, which usually accompanies the heat shock response, may protect the cell from the large-scale synthesis of abnormal RNA's and aberrant proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
242
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1544-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Translation of unspliced transcripts after heat shock.
pubmed:affiliation
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.