Linked Life Data

3198985

Source:http://linkedlifedata.com/resource/pubmed/id/3198985

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-1-25
pubmed:abstractText
The Emory mouse develops a late-onset hereditary cataract bearing some resemblances to human senile cataract. It was used as a model system for testing the effects of several drugs expected to have anticataractogenic potential. A low level of added dietary alpha-tocopherol had only a marginal effect. Penicillamine increased lens soluble protein, a good index of lens viability. Triethylenetetramine was too toxic to permit satisfactory treatment. Mercaptopropionylglycine produced several positive effects including a retardation of cataract at 6 months of age; parameters which increased under drug treatment were lens weight, soluble protein content and protein sulfhydryl, but not glutathione. There was no effect on the total calcium concentration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
8756-3320
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-51
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The Emory mouse cataract: the effects on cataractogenesis of alpha-tocopherol, penicillamine, triethylenetetramine, and mercaptopropionylglycine.
pubmed:affiliation
Department of Ophthalmology, Emory University, Atlanta, Georgia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't