Linked Life Data

3196523

Source:http://linkedlifedata.com/resource/pubmed/id/3196523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-1-26
pubmed:abstractText
Three-beta-methyl-iodophenyl-pentadecanoic acid (BMIPP), a newly developed radiographic probe of metabolic processes in tissue free fatty acid (FFA), was applied to a study analyzing the effect of a left ventricular assist device (LVAD) on impaired dog hearts. The radiographic image obtained with BMIPP was compared with 201thallium chloride (TL) imaging, which indicates tissue perfusion. In the myocardial infarction (MI) model, the BMIPP and TL uptake were equally increased with the use of LVAD in the marginal area of the MI. In another model using the reperfused myocardium after ischemia, the BMIPP and TL uptake were increased in the reperfused area by LVAD pumping. On the other hand, BMIPP uptake in the residual myocardium of both models was decreased by LVAD pumping when compared with TL uptake. This discrepancy between these radiographic tracers in the residual myocardium suggests that tissue metabolic processes may be suppressed as result of a decrease in the energy demand by the myocardium caused by LVAD pumping. The results of this study showed that use of LVADs for the impaired heart improved cell function of "stunned" myocardium and also unloaded the excess work from the residual myocardium as judged by FFA metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0889-7190
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Myocardial free fatty acid metabolism of the ischemic heart treated by left ventricular assist device.
pubmed:affiliation
Department of Artificial Organs, National Cardiovascular Center, Osaka, Japan.
pubmed:publicationType
Journal Article, Comparative Study