Linked Life Data

3196474

Source:http://linkedlifedata.com/resource/pubmed/id/3196474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1989-1-26
pubmed:abstractText
The diarrheic activity of algal toxins in blue mussels (Mytilus edulis) has been quantitatively determined in ligated intestinal loops of the rat. Hepatopancreas from toxic mussels were disintegrated by freeze-pressing, and the homogenized tissue suspended in an equal amount (w/v) of buffer or in the liquid recovered after steaming. When such suspensions were injected into ligated loops of rat small intestine a rapid fluid secretion was observed. In contrast, the liquid from non-toxic mussel tissue homogenate was absorbed. Toxic tissue homogenates, liquid recovered after steaming of toxic mussels as well as purified okadaic acid produced maximum fluid accumulation in the loops within two hours. The maximum net fluid accumulation observed was ca 300 mg of weight increase per cm length of intestine. Within a range of 50-200 mg/cm the dose-response relationship was close to linear (r = 0.96, 0.99). In duplicate tests the average deviation from the mean was +/- 9 mg/cm (SD = +/- 4.9). Mussels yielding less than 100 mg/cm of weight increase per g hepatopancreas have been allowed for human consumption, a quantity agreeing with the allowed level of okadaic acid. The minimum quantity of okadaic acid which produced significant secretion in the rat intestinal ligated loop test was approx. 0.5 microgram. On a body weight basis, therefore, humans are estimated to be at least four times as sensitive as the rat to enteral challenge with okadaic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0903-4641
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1029-35
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine.
pubmed:affiliation
Department of Clinical Bacteriology, University of Göteborg, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't