Linked Life Data

3196224

Source:http://linkedlifedata.com/resource/pubmed/id/3196224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-1-10
pubmed:abstractText
The separate effects of dietary composition and time of nutrient intake on apoprotein B (apo B) gene expression in rabbit intestine and liver were determined. After an overnight fast, there were insignificant effects of the long-term consumption of a diet containing saturated fat on the tissue levels of apo B mRNA, although plasma cholesterol levels were elevated as compared to those of animals consuming a diet containing unsaturated fat. However, when the animals were studied 2 hours after receiving a gastric tube feeding of a portion of their test diets after an overnight fast, there was a twofold increase in the intestinal apo B mRNA level and a similar increase in the transcriptional activity of the apo B gene independent of dietary composition. We conclude that, with the diets we used, nutrient intake alone has, in rabbits, a major effect on apo B gene expression at the level of transcription. This factor should be taken into account when designing studies of intestinal gene expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0276-5047
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
797-803
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Independent effects of diet and nutritional status on apoprotein B gene expression in rabbit.
pubmed:affiliation
Department of Physiology and Biochemistry, Medical College of Pennsylvania, Philadelphia 19129.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't