Linked Life Data

3196156

Source:http://linkedlifedata.com/resource/pubmed/id/3196156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1988-12-29
pubmed:abstractText
Earlier studies have shown that intraperitoneal injection of the industrial solvent sulfolane (tetrahydrothiophene-1,1-dioxide) caused a decrease in metabolic rate and a rapid, regulated hypothermia in mice and rats. In the present study, subcutaneous injections of 0, 100, 200, 400, 600, and 750 mg/kg sulfolane at an ambient temperature (Ta) of 10 degrees C caused a dose-dependent decrease in colonic temperature (Tc) of rabbits. Metabolic rate (MR) remained unchanged during the initial phase of the hypothermia for all dose groups; but peripheral vasodilation, as indicated by an increase in ear skin temperature, was seen at the higher dose levels. The observed thermoregulatory response to sulfolane was a function of Ta. Thus, at Tas of 10 and 20 degrees C, injection of 600 mg/kg sulfolane had no effect on MR but caused an increase in ear skin temperature. The magnitude of the hypothermia was similar at these two Tas, indicating the sulfolane-treated rabbits had some control over Tc. At a Ta of 28 degrees C, however, the animals became hyperthermic upon injection of 600 mg/kg sulfolane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Thermoregulatory responses of the rabbit to subcutaneous injection of sulfolane.
pubmed:affiliation
United States Environmental Protection Agency, Health Effects Research Laboratory, Research Triangle Park, North Carolina 27711.
pubmed:publicationType
Journal Article