3195994

Source:http://linkedlifedata.com/resource/pubmed/id/3195994

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0042313, umls-concept:C0086045, umls-concept:C0086418, umls-concept:C0262950
pubmed:issue	9
pubmed:dateCreated	1989-1-3
pubmed:abstractText	Concentrations of vancomycin in bones of 14 patients undergoing total hip arthroplasty (group 1) and 5 patients with osteomyelitis (group 2) were studied. Group 1 received vancomycin, 15 mg/kg intravenously, 1 h prior to anesthesia. Group 2 received doses adjusted to achieve peak levels in serum of 20 to 30 micrograms/ml and trough levels of less than 12 micrograms/ml; bone specimens were collected during surgical debridement. The specimens were pulverized and eluted into phosphate buffer, and the supernatants were analyzed for vancomycin content by fluorescence polarization immunoassay. In group 1, vancomycin was detectable in all cancellous specimens with a mean concentration of 2.3 +/- 4.0 micrograms/g (range, 0.5 to 16 micrograms/g); 10 of 14 cortical specimens had detectable vancomycin; the mean cortical concentration was 1.1 +/- 0.8 micrograms/g (range, not detectable to 2.6 micrograms/g). In group 2, vancomycin was detectable in only two of five cortical bone specimens (mean concentration, 5.9 +/- 3.5 micrograms/g). Cancellous bone was obtained in one patient; the vancomycin concentration was 3.6 micrograms/g. In most patients the vancomycin levels in bones were higher than the MIC for susceptible staphylococci following single prophylactic doses. In the few infected patients studied, penetration was variable and deserves further study.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-1157411, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-1259390, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-251180, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-3453955, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-4257779, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-619056, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-649639, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-6522920, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-6703678, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-6805423, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-708013, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-7226972, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-735781, http://linkedlifedata.com/resource/pubmed/commentcorrection/3195994-908715
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Vancomycin
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0066-4804
pubmed:author	pubmed-author:GibsonG AGA, pubmed-author:GrazianoA FAF, pubmed-author:LawsonL ALA, pubmed-author:MacGregorR RRR, pubmed-author:SteinbergM AMA
pubmed:issnType	Print
pubmed:volume	32
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1320-2
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:3195994-Adult, pubmed-meshheading:3195994-Bone and Bones, pubmed-meshheading:3195994-Hip Prosthesis, pubmed-meshheading:3195994-Humans, pubmed-meshheading:3195994-Osteomyelitis, pubmed-meshheading:3195994-Vancomycin
pubmed:year	1988
pubmed:articleTitle	Vancomycin concentrations in infected and noninfected human bone.
pubmed:affiliation	Pharmacy and Drug Information Services, Hospital of the University of Pennsylvania, Philadelphia.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't