Linked Life Data

3194422

Source:http://linkedlifedata.com/resource/pubmed/id/3194422

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1988-12-30
pubmed:abstractText
Infection with the human immunodeficiency virus type 1 (HIV-1) is usually followed by a vigorous immune response that temporarily protects against disease progression. After a variable asymptomatic period, acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and AIDS develop in most infected individuals. We have demonstrated that healthy HIV-1-infected individuals have neutralizing antibodies and a high titer of antiviral antibodies. In contrast, AIDS patients have undetectable levels of neutralizing antibodies, low titers of antiviral antibodies, and, frequently, HIV p24 antigenemia. These observations prompted us to attempt passive immunization in ARC and AIDS patients. Ten consistently viral-antigen-positive patients (mean, greater than 6 months) were treated, resulting in sustained clearance of p24 antigen. Patients either maintained or increased their antiviral antibody titers. The raised titers result from increased antibody synthesis by the recipients. Circulating CD4+ cell counts were unchanged after 2 months. By the third month none of these patients remained in hospital. As this treatment was of minimal toxicity, it merits wider evaluation in ARC and AIDS patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2425430, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2439855, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2863680, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2884436, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2893187, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2896890, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-2989706, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-3126959, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-3128995, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-3475581, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-6094957, http://linkedlifedata.com/resource/pubmed/commentcorrection/3194422-6189183
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
9234-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome.
pubmed:affiliation
Department of Hematological Medicine, Cambridge University Clinical School, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't